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Document Type |
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Article In Journal |
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Document Title |
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Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors |
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Document Language |
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English |
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Abstract |
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BACKGROUND: Rheumatoid arthritis (RA) and periodontitis are common chronic
inflammatory conditions. Recent studies showed a beneficial effect of periodontal
treatment on the severity of active RA. This study was undertaken to further
examine the effect of non-surgical periodontal treatment on the signs and
symptoms of RA in patients treated with or without anti-tumor necrosis
factor-alpha (anti-TNF-alpha) medications. The effect of anti-TNF-alpha therapy
on periodontitis also was assessed. METHODS: Forty participants diagnosed with
moderate/severe RA (under treatment for RA) and severe periodontitis were
randomly assigned to receive initial non-surgical periodontal therapy with
scaling/root planing and oral hygiene instructions (n = 20) or no periodontal
therapy (n = 20). To control RA, all participants had been using
disease-modifying anti-rheumatic drugs, and 20 had also been using anti-TNF-alpha
before randomization. Probing depth (PD), clinical attachment level (CAL),
bleeding on probing (BOP), gingival index (GI), plaque index (PI), RA disease
activity score 28 (DAS28), and erythrocyte sedimentation rate (ESR) were measured
at baseline and 6 weeks later. Linear mixed models were used to identify
significant differences between subjects who received periodontal treatment and
those who did not. RESULTS: Patients receiving periodontal treatment showed a
significant decrease in the mean DAS28, ESR (P <0.001), and serum TNF-alpha (P
<0.05). There was no statistically significant decrease in these parameters in
patients not receiving periodontal treatment. Anti-TNF-alpha therapy resulted in
a significant improvement in CAL, PD, BOP, and GI. CONCLUSIONS: Non-surgical
periodontal therapy had a beneficial effect on the signs and symptoms of RA,
regardless of the medications used to treat this condition. Anti-TNF-alpha
therapy without periodontal treatment had no significant effect on the
periodontal condition. |
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ISSN |
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0 |
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Journal Name |
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. J Periodontol |
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Volume |
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4 |
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Issue Number |
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1 |
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Publishing Year |
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2009 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, February 21, 2010 |
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Researchers
| محمد الزهراني | Al-Zahrani, Mohammad | Researcher | Doctorate | |
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